Natural killer cells: the first defense against human papilloma virus early infection

Natural killer (NK) cells contribute innate immunity against transformed cells. Clinical data indicate that cancer patients benefit from the adoptive transfer therapy based on vigorous NK cells. In this review, with the aim of effective prevention and quick control of human papilloma virus (HPV) caused cervical cancer, we summarized the regulatory mechanisms of HPV on NK cells, and highlighted the important role of the artificial induced NK cells in HPV early infection.